Retiform Purpura Associated With Protein S Deficiency
نویسندگان
چکیده
منابع مشابه
Familial protein S deficiency is associated with recurrent thrombosis.
Recent studies have demonstrated that protein C deficiency is associated with recurrent familial thrombosis. In plasma, activated protein C functions as an anticoagulant. This anticoagulant response requires a vitamin K-dependent plasma protein cofactor, referred to as protein S. Since the anticoagulant activity of activated protein C is dependent on protein S, we hypothesized that patients lac...
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Sir, Non-inflammatory retiform (net-like or livedoid) purpura (NIRP) is a clinical pattern produced by small vessel occlusion in dermis. Several disorders such as coagulation abnormalities, cold-related gelling, microorganism vessel invasion or embolization leading to microvascular occlusion may share in common a clinical picture of localized or generalized NIRP (1). NIRP lesions are usually sh...
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quent inhalational cocaine use was admitted to hospital after presenting to the emergency department with a four-month history of intermittent painful bruises (retiform purpura) involving her arms and legs, with recent ulceration of her nasal tip, ears and cheeks (Figures 1A, 2A and 3A). Previous episodes of the retiform purpura had improved spontaneously following abstinence from inhalational ...
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Neonatal purpura fulminans is a life threatening clinical entity characterized by extensive subcutaneous thrombosis and disseminated intravascular coagulation usually manifesting shortly after birth. We report an autosomal recessive form of the disease in a neonate who was diagnosed with compound heterozygosity for mutations in his protein C gene as the molecular basis of his disorder.
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ژورنال
عنوان ژورنال: Actas Dermo-Sifiliográficas (English Edition)
سال: 2016
ISSN: 1578-2190
DOI: 10.1016/j.adengl.2016.03.019